MANUSCRIPT CONTENT

1) COVER LETTER

The corresponding author should be specified in the cover letter. All editorial communications and submission queries will be sent to this author. See also “Authorship.” Cover letters must include the following 4 ICJME Statements:

1) the paper is not under consideration elsewhere;

2) none of the paper’s contents have been previously published;

3) all authors have read and approved the manuscript;

4) the full disclosure of any potential conflict of interest (see “Relationship With Industry Policy”) or that no such relationship exists. Exceptions must be explained. If there is no conflict of interest, this should also be stated in the cover letter.

5) Ethical Approval (required): Please denote that your study received the proper ethical oversight in both your cover letter and the body of the article. For manuscripts reporting data on human subjects, note institutional review board/ethics committee approval (or formal review and exemption), including the specific name of the board or committee. For studies involving animal experiments, note that the study complied with all institutional and national requirements for the care and use of laboratory animals and, if applicable, received animal care and use committee approval. State the animal-handling protocol in the body of your research correspondence or the Methods section of your manuscript.

2) TITLE PAGE

Include the full title (no more than 15 words, hyphenated words count as a single word and single terms [e.g., de novo, in vivo, etc.] count as a single word), authors’ names (full given name, middle initial, and surname), degree, total word count, and a running title of #7words.

List the departments and institutions with which the authors are affiliated, and indicate the specific affiliations if the work is generated from more than one institution (use superscript letters a, b, c, d, and so on). Provide information on clinical trials, grants, contracts, and other forms of financial support, and list the cities and states of all foundations, funds and institutions involved in the work. This must include the full disclosure of any relationship with industry (see “Relationship With Industry Policy”). If there are no relationships with industry, this should be stated. Under the heading, “Address for correspondence,” give the full name and complete postal address of the author to whom communications, printer’s proofs, and reprint requests should be sent. Also provide telephone and fax numbers and an email address for the corresponding author.

Word Count: Word count should include text, references, and figure legends.

3) STRUCTURED ABSTRACT

Provide a Structured Abstract of #250 words, presenting essential data in 5 paragraphs introduced by separate headings in the following order: Objectives, Background, Methods, Results, and Conclusions. Please denote that your study received the proper ethical oversight in your methods section. Use complete sentences. All data in the Abstract must also appear in the manuscript text or tables. For general information on preparing Structured Abstracts, see “Haynes RB,Mulrow CD, Huth EJ, Altman DG, GardnerMJ. More informative abstracts revisited. Ann Intern Med 1990;113:69–76.” An Unstructured Abstract is appropriate for review articles.

4) KEY WORDS Include 3-5 KeyWords.

5) CONDENSED ABSTRACT

Provide a Condensed Abstract of#100words, stressing clinical implications, for the expanded table of contents. Include no data that do not also appear in the manuscript text or tables.

6) UNSTRUCTURED ABSTRACT

For State-of-the-Art Reviews, Viewpoints, and Interventional Issues only, provide an Unstructured Abstract of #250 words.

7) ABBREVIATIONS

The abbreviations of common terms (e.g., ECG, PTCA, CABG) or acronyms (GUSTO, SOLVD, TIMI) may be used in the manuscript. On a separate page following the Condensed Abstract, list the selected abbreviations and their definitions (e.g.,TEE¼transesophageal echocardiography). The Editors may determine which lesser-known terms should not be abbreviated. Please consult “Recommendations for the Conduct, Reporting, Editing and Publication of Scholarly Work in Medical Journals (ICMJE Recommendations),” available from www.ICMJE.org for appropriate use of units of measure.

8) TEXT

All text from the Introduction to the end of the manuscript should be double spaced. Page numbering should start with the Title Page. The text for Original Research Papers should be structured as Introduction, Methods, Results, Discussion, and Conclusions. Use headings and subheadings in the Methods, Results, and particularly, Discussion sections. Every reference, figure, and table should be cited in the text in numerical order according to order of mention.

Statistics: All publishable original research manuscripts will be reviewed for appropriateness and accuracy of statistical methods and statistical interpretation of results. We subscribe to the statistics section of the “Recommendations for the Conduct, Reporting, Editing and Publication of ScholarlyWork inMedical Journals (ICMJERecommendations),” available at http://www.ICMJE.org. In the Methods section, “provide a subsection detailing the statistical methods, including specific methods used to summarize the data, methods used for hypothesis testing (if appropriate), and the level of significance used for hypothesis testing. When using more sophisticated statistical methods (beyond t-tests, chi-square, or simple linear regression), specify the statistical package, version number, and nondefault options used. Formore information on statistical review, see “Glantz SA. It is all in the numbers. J Am Coll Cardiol 1993;21:835–7.”

9) PERSPECTIVES

For Original Research Papers, authors should outline the following:

What Is Known? (what is the background that generates the question that is being addressed);

What Is New? (what did this study add);

What Is Next? (what is needed to improve our knowledge base).

These should be no longer than 1 paragraph, i.e. 3–4 sentences. Authors are asked to consider the clinical implications of their paper and identify areas of clinical relevance that could be used by clinician readers as professional caregivers. This applies not only to physicians in training, but also to the sustained commitment to education and continuous improvement across the span of their professional careers.

10) ACKNOWLEDGMENTS

Acknowledgments or appendices must be #100 words. Text exceeding this limit will appear in the online version only. Signed letters of permission from all individuals listed in the acknowledgments must be submitted to JACC: Cardiovascular Interventions prior to publication.

11) REFERENCES

Identify references in the text by Arabic numerals in parentheses on the line. The reference list should be typed double-spaced on pages separate from the text. The references should be numbered consecutively in the order in which they are cited in the text. Do not cite personal communications, manuscripts in preparation, or other unpublished data in the references; however, these may be included in the text in parentheses. Do not cite abstracts that are older than 2 years. Identify abstracts by the abbreviation “abstr” in parentheses. If To the Editor are cited, identify them with the word “letter” in parentheses. Use Index Medicus (National Library of Medicine) abbreviations for journal titles. It is important to note that when citing an article from the JACC: Cardiovascular Interventions, the correct citation format is JAmColl Cardiol Intv.

Use the following style and punctuation for references:

A. Periodical

List all authors if 6 or fewer; otherwise, list the first 3 and add “et al.” Do not use periods after the authors’ initials. Please provide inclusive page numbers as in the example below.

5. Rossini R, Tarantini G, Musumeci G, et al. A multidisciplinary approach on the perioperative antithrombotic management of patients with coronary stents undergoing surgery: surgery after stenting 2. J Am Coll Cardiol Intv 2018; 11:417-434.

B. Doi-based citation for an article in press

If the ahead-of-print date is known, please provide this as in the example below.

5. Ahn SG. Discordance between fractional flow reserve and coronary flow reserve: insights from intracoronary imaging and physiological assessment. J Am Coll Cardiol Intv 2017 May 22 [E-pub ahead of print], http://doi: 10.1016/j.jcin.2017.03.006.

If the ahead-of-print date is unknown, it is okay to omit as in the example below.

5. Ahn SG. Discordance between fractional flow reserve and coronary flow reserve: insights from intracoronary imaging and physiological assessment. J Am Coll Cardiol Intv 2017 [E-pub ahead of print], https:// doi.org/10.1016/j.jcin.2017.03.006.

C. Chapter in book

Provide authors, chapter title, editor(s), book title, publisher location, publisher name, year, and inclusive page numbers.

5. Ziada KM, Messerli AW, Mukherjee D. Periprocedural myocardial infarction and embolism-protection devices. In: Topol EJ, Teirstein PS, editors. Textbook of Interventional Cardiology. Philadelphia, PA. Elsevier, 2016:482-504.

D. Book (personal author or authors)

Provide a specific (not inclusive) page number.

23. Cohn PF. Silent Myocardial Ischemia and Infarction. 3rd edition. New York, NY: Marcel Dekker, 1993:33.

E. Online Media

Provide specific URL address and date information was accessed.

ACC Cardiology Hour at ACC.18 with Dr. Valentin Fuster. Available at http://www.onlinejacc.org/cardiologyhour?_ga¼2.144082102.2042197087. 1522360261-381695815.1493137865. Accessed March 29, 2018.

F. Material presented at a meeting but not published

Provide authors, presentation title, full meeting title, meeting dates, and meeting location.

5. Kolte D, Khera S, Vemulapalli S, et al. Outcomes Following Urgent/Emergent Transcatheter Aortic Valve Replacement: Insights from the STS/ACC TVT Registry. Paper presented at: ACC.18; March 11, 2018; Orlando, FL.

12. FIGURE LEGENDS

Figure legends should be typed double-spaced on pages separate from the text; figure numbers must correspond with the order in which they are mentioned in the text. All abbreviations used in the figure should be identified either after their first mention in the legend or in alphabetical order at the end of each legend. All symbols used (arrows, circles, etc.) must be explained.

ALL FIGURES MUST HAVE A TITLE.

For example, Figure 1. Title: Kaplan-Meier Survival Estimates for the Occurrence of the Primary Endpoint. Legend: Plot of survival functions for transcatheter intervention versus surgical intervention.

If previously published figures are used, written permission from the original publisher is required: see STM Guidelines for details: http://www.stm-assoc. org/permissions-guidelines/. Cite the source of the figure in the legend.

13. FIGURES

Figures and graphs submitted in electronic format should be provided in EPS or TIF format. Graphics software such as Photoshop and Illustrator, NOT presentation software such as PowerPoint CorelDraw, or Harvard Graphics, should be used to create the art.

• Color images must be at least 300 DPI.

• Gray scale images should be at least 300 DPI.

• Line art (black and white or color) should be at least 1,200 DPI

• Combinations of gray scale images and line art should be at least 1,200 DPI.

Lettering should be of sufficient size to be legible after reduction for publication. The optimal size is 12 points. Symbols

should be of a similar size. Figures should be no smaller than 13 cm x 18 cm (5"x 7"). Please do not reduce figures to fit publication layout. If the manuscript is accepted for publication, the publisher will re-size the figures accordingly.

There is no fee for the publication of color figures. Our editors encourage authors to submit figures in color, as we feel it improves the clarity and visual impact of the images. If your original submission contains any line art or black and white figures that you would like to change to color, please email the revised color figures to the JACC : Cardiovascular Interventions editorial office during the revision process. Be sure to include correspondence, with the manuscript number, explaining the change. Decimals, lines, and other details must be strong enough for reproduction.

Use only black and white, not gray, in charts and graphs. Place crop marks on photomicrographs to show only the essential field. Designate special features with arrows. All symbols, arrows, and lettering on halftone illustrations must contrast with the background.

Upon provisional acceptance, we may request 2 sets of glossy or laser print (clean copies will suffice) hard copies of the figures. Glossy prints should be provided for all half-tone or color illustrations. All graphs and line drawings must be professionally prepared on a computer and reproduced as high-quality laser prints. Indicate the first author’s last name (and the corresponding author’s last name within parentheses, if different) and the figure number on the back of each figure, preferably on an adhesive label. Figure title and legend material should appear on the legends page in the manuscript, not on the figure.

Note: If we request hard copies, they will not be returned to authors.

14. CENTRAL ILLUSTRATIONS

The final version of all Original Research Papers and State-of-the-Art Reviews should include 1 Central Illustration, which summarizes the main point of the manuscript or at least a major section of the manuscript (it can be simple and hand-drawn).

If one of the figures already provided in your manuscript is a key figure summarizing the major findings, you may designate that figure as the Central Illustration in the legend.

The figure may incorporate multiple panels including key figures or graphics, or short text lists summarizing key points or variables. The purpose of these illustrations is to provide a snapshot of your paper in a single visual or conceptual manner. This illustration should be accompanied by a legend (title and caption). The Central Illustration should be an original image and, for copyright reasons, should not be adapted or reprinted from another source.

15. TABLES

Tables should be typed double-spaced on separate sheets, with the table number and title centered above the table and explanatory notes below the table. Use Arabic numbers. Table numbers must correspond with the order cited in the text. Abbreviations should be listed in a footnote under the table in alphabetical order. Footnote symbols should appear in the following order: *, y, z, x, jj, {, #, **, yy, etc.

ALL TABLES MUST HAVE A TITLE.

Tables should be self-explanatory, and the data presented in them should not be duplicated in the text or figures.

If previously published tables are used, written permission from the copyright holder (typically the original publisher) is required. In such cases, cite the source of the table in the legend.

16. SUPPLEMENTAL MATERIALS

Authors are encouraged to enhance their manuscript with media files, additional images, web-based calculators, and other material that does not fit into the usual format of an article but that helps communicate results and/or educate the reader.

Video Requirements:

Inclusion of videos in the published paper is at the discretion of the Editors.

1. Video submissions for viewing online should be submitted as MP4 files only. The Journal office will not accept any other file formats.

2. Videos should be brief (<2–4 min). Longer videos will require longer download times and may have difficulty playing online. Videos should be restricted to the most critical aspects of your research. A longer procedure can be restructured as several shorter videos and submitted in that form.

3. It is advisable to compress files to use as little bandwidth as possible and to avoid overly long download times. Video files should be less 5 megabytes. This is a suggested maximum. If files are larger, please contact the JACC: Cardiovascular Interventions office at jaccint@acc.org.

4. A video legends page giving a brief description of the content of each video should be included in the manuscript. Please note that ALL videos must be linked to figures or panels of a figure(s).

5. If your paper is accepted for publication you may wish to supply the editorial office with several different resolutions of your video files. This will allow viewers with slower connections to download a lower resolution version of your video.